The binomial coefficient $\displaystyle{\binom{10^{18}}{10^9}}$ is a number with more than $9$ billion ($9\times 10^9$) digits.

Let $M(n,k,m)$ denote the binomial coefficient $\displaystyle{\binom{n}{k}}$ modulo $m$.

Calculate $\displaystyle{\sum M(10^{18},10^9,p\cdot q\cdot r)}$ for $1000\lt p\lt q\lt r\lt 5000$ and $p$,$q$,$r$ prime.